Join Our Members

Magnetic Resonance Imagings

MRI Applications

Apparatus and Method for Detecting Cancer in Tissue
Patent Number(s) 3,789,832

Raymond V. Damadian, inventor of the Magnetic Resonance (MR) scanning machine, was born in Forest Hills, New York in 1936. He studied violin at the Julliard School of Music in New York for eight years before winning a scholarship, at age 16, to the University of Wisconsin. There he received a BS in mathematics in 1956 and then turned to medicine, earning an MD in 1960 from the Albert Einstein College of Medicine (Bronx, NY).

After his internship, residency, and Fellowships at Washington University and Harvard, Dr. Damadian served for some time in the Air Force, then joined the faculty of SUNY Downstate Medical Center. There, his research into sodium and potassium in living cells led him to his first experiments with nuclear magnetic resonance (NMR) which caused him to first propose the MR body scanner in 1969.

NMR, the phenomenon of atomic nuclei emitting radio waves at predictable frequencies when exposed to a powerful magnetic field, had been used during and after World War II to probe the composition of various substances. Damadian invented an apparatus and method to use NMR safely and accurately to scan the human body, a method now well known as magnetic resonance imaging (MRI).

Experimenting on rats, Damadian discovered dramatic differences in the quality and duration of NMR signals emitted by cancerous versus healthy tissues that confirmed his idea of the MR body scanner. His 1971 paper, "Tumor Detection by Magnetic Resonance," was met with skepticism from the scientific community, but Damadian forged ahead, filing the first of his patents for an MRI scanner the next year. The scanner used liquid helium to supercool magnets in the walls of a cylindrical chamber; the nuclei of hydrogen atoms in the water, which all cells contain, reacted to the resultant magnetic field, and a three-dimensional spatial localization method coordinated the signals into the scan.

Damadian spent the next years working with teams of graduate students to make his scanner a reality. Meanwhile, many scientists had decided that Damadian's ideas were not so misguided after all and began to compete to develop the first workable scanner. Finally, in 1977, Damadian's team produced the first MRI scan of the human body, using a prototype device he called "Indomitable" (now installed in the Smithsonian Institution).

The first MRI scan provided a clear image of the heart, lungs and chest wall with no side effects. Today, MRI scanners can instantly map and analyze any part of the human body in minute detail, allowing visual diagnosis of virtually any medical condition, from strained muscles to tumors. They can also provide the chemical composition of the tissue being scanned.

In 1978, Damadian formed a company, FONAR Corporation (from "Field fOcused Nuclear mAgnetic Resonance"), which produced the first commercial scanner in 1980. Later the company developed the first FDA-approved, first mobile, and first whole-body MR scanners. FONAR's patented Iron Circuit™ technology has enabled the company to develop seven different MRI products including the recently cleared-for-marketing FONAR 360°, a full-size room with two circular structures (the poles of the magnet) projecting from the ceiling and the floor. There are no obstructions between the patient and the walls of the scanner room, and the patient is accessible from any direction. Damadian is also working on the Stand-Up MRI™, the only scanner that allows MRI patients to be scanned while standing up.

Damadian continues to direct FONAR's scientific and financial progress, as Chairman and President. He has earned over 40 patents, as well as the 2001 Lemelson-MIT Program's Lifetime Achievement Award, a National Medal of Technology (1988), and induction into the National Inventors Hall of Fame (1989).

New MR applications improve diagnostics